GSK-626616
- Product Name
- GSK-626616
- CAS No.
- 1025821-33-3
- Chemical Name
- GSK-626616
- Synonyms
- GSK-626616;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- CBNumber
- CB63303333
- Molecular Formula
- C18H10Cl2N4OS
- Formula Weight
- 401.27
- MOL File
- 1025821-33-3.mol
GSK-626616 Property
- Melting point:
- 281 - 282oC
- Boiling point:
- 574.8±60.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly)
- pka
- -0.94±0.20(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML3355
- Product name
- GSK626616
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $87
- Updated
- 2024/03/01
- Product number
- SML3355
- Product name
- GSK626616
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $350
- Updated
- 2024/03/01
- Product number
- 6638
- Product name
- GSK626616
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $861
- Updated
- 2021/12/16
- Product number
- 6638
- Product name
- GSK626616
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $205
- Updated
- 2021/12/16
- Product number
- G797853
- Product name
- GSK-626616
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
GSK-626616 Chemical Properties,Usage,Production
Uses
GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
storage
Store at +4°C